In the field of antibody - drug conjugates (ADCs) and bispecific antibodies, the selection of appropriate antibody linkers is crucial. CD ComputaBio offers a specialized antibody linkers selection service based on computational modeling. This service aims to assist researchers and pharmaceutical companies in choosing the most suitable linkers for their antibody - based projects, optimizing the performance, stability, and efficacy of the final constructs.
For ADCs, the linker should be stable in circulation to prevent premature release of the cytotoxic drug, but also cleavable at the target site to deliver the drug effectively. In bispecific antibodies, the linker needs to maintain the proper orientation and flexibility of the connected antibody fragments to ensure correct binding to the two different antigens.
Customized Linker Design
CD ComputaBio offers customized linker design based on the specific requirements of the antibody and its intended application. Whether it is for a particular target antigen, a specific antibody format, or a desired pharmacokinetic profile, we can design linkers from scratch.
Linker - Antibody Compatibility Assessment
We assess the compatibility between the proposed linker and the antibody. This includes analyzing how the linker may interact with the antibody's amino acid residues, its effect on the antibody's folding and stability, and potential steric hindrance issues.
Linker Property Prediction
Our service predicts various properties of the linkers, such as their flexibility, rigidity, and solubility. These properties are crucial for determining how the linker will behave in different physiological environments. We can also predict the linker's susceptibility to enzymatic cleavage, which is important for ADCs where controlled drug release is desired.
High - Throughput Screening
CD ComputaBio uses computational modeling to perform high - throughput screening of a large library of linkers. This allows us to quickly identify potential candidates that meet the desired criteria. The screening process can be customized based on different parameters such as linker length, chemical composition, and cleavage mechanism.
Amber
CHARMM
GROMACS
Expertise in Antibody Biology
CD ComputaBio has a team of experts with in - depth knowledge of antibody biology. They understand the nuances of antibody structure, function, and antigen binding, which is essential.
Computational Resources
We have access to high - performance computing resources, which are necessary for running complex computational models and simulations.
Data - Driven Decision - Making
CD ComputaBio has amassed a large amount of data on antibody - linker interactions, both from in - house research and from the scientific literature.
Antibody linkers selection is a critical step in the development of antibody - drug conjugates. CD ComputaBio's antibody linkers selection service, with its diverse feature services, multiple approaches, advanced algorithms, and significant advantages, offers a comprehensive and efficient solution for choosing the most suitable linkers. By relying on computational modeling, we can accelerate the development of ADCs with improved efficacy and safety profiles.
